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| Week 5 | |||||
| Thursday Oct. 8, 2026 | |||||
| Tampa Bay | 24 | at | 16 | Dallas | |
| Sunday Oct. 11, 2026 | |||||
| Philadelphia | 17 | at | 19 | Jacksonville | |
| Houston | 26 | at | 3 | Tennessee | |
| Cincinnati | 31 | at | 24 | Miami | |
| Las Vegas | 17 | at | 45 | New England | |
| Minnesota | 23 | at | 13 | New Orleans | |
| Cleveland | 12 | at | 17 | New York | |
| Indianapolis | 22 | at | 34 | Pittsburgh | |
| New York | 27 | at | 27 | Washington | |
| Denver | 23 | at | 17 | Los Angeles | |
| Chicago | 7 | at | 31 | Green Bay | |
| Detroit | 45 | at | 21 | Arizona | |
| San Francisco | 32 | at | 29 | Seattle | |
| Baltimore | 30 | at | 23 | Atlanta | |
| Monday Oct. 12, 2026 | |||||
| Buffalo | 37 | at | 34 | Los Angeles | |
| Bye Teams: | Kansas City | Carolina |