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| Week 5 | |||||
| Away Team | Home Team | ||||
| Friday Oct. 2, 2026 | |||||
| Penn State | 13 | at | 34 | Northwestern | |
| Saturday Oct. 3, 2026 | |||||
| Purdue | 24 | at | 17 | Illinois | |
| #5 Ohio State | 31 | at | 14 | #14 Iowa | |
| Michigan | 14 | at | 20 | Minnesota | |
| Maryland | 23 | at | 48 | Nebraska | |
| Washington | 21 | at | 25 | #18 USC | |
| Michigan State | 3 | at | 31 | Wisconsin | |
| #6 Indiana | 47 | at | 15 | Rutgers | |